The Pathogenic Role of Vascular Endothelial Growth Factor (VEGF) in Skin Diseases


Aziz Alsohaimi


Vascular endothelial growth factor (VEGF), first isolated in 1989, is now considered the key mediator for the process of angiogenesis involved in many developmental, physiological, and pathological conditions. Studies have shown that VEGF family consists of 5 isoforms with similar biological activity but differ in their target receptor activity; the most important of them being the VEGF-A. Studies have also defined the presence of 3 types of VEGF receptors predominantly located on vascular endothelial, stromal, and hematopoietic cells. Recent research has shed light on VEGF as a key mediator of angiogenesis in many pathological conditions such as tumor growth and metastasis. Likewise, there have been intensive efforts to clarify the pathogenic role of VEGF/VEGFRs in skin diseases. VEGF and its receptors are also investigated as pivotal players in many skin diseases such as psoriasis, atopic dermatitis, chronic inflammatory skin diseases, phototoxicity, and dysregulated differentiation/proliferation of dermal and epidermal cells. Therefore, in this review, we will discuss the implication of VEGF as a pathogenic biomarker for skin disorders by discussing the available experimental and clinical evidences for the potential role of VEGF in some dermatologic disorders.


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Vascular endothelial growth factor, Angiogenesis, Psoriasis, Lichen planus, Wound healing

How to Cite
Alsohaimi, A. (2019). The Pathogenic Role of Vascular Endothelial Growth Factor (VEGF) in Skin Diseases. Advances in Medicine and Medical Research, 2(1), 27-37.
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