Hepatic Ischemia-Reperfusion Injury: Pathogenesis and Pharmacological Treatment Submitted: Dec 11, 2017 Accepted: Jan 28, 2018 Published online: Feb 5, 2018

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Sameh A. Abdel-Ghany Hala A. Elashry Maha M. Ameen Karawan M. Abdel-Rahman Abdel-Rahman A. Yassin

Abstract

Hepatic ischemia reperfusion injury (R/I) is a hepatic pathophysiologic process occurs post liver transplantation surgery. It also comprises complex systemic process affecting multiple tissues and organs. Hepatic I/R has serious impact on liver function, even producing irreversible failure, which may trigger multiple organ dysfunction. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secretion of reactive oxygen species (ROS), intracellular calcium overload, cytokines and chemokines produced by Kupffer cells (KCs) and neutrophils are involved in the pathogenesis of hepatic I/R processes. There are many treatment options to combat hepatic I/R injury but none has shown clear beneficial clinical evidence. The purpose of this review is to provide insights into the mechanisms of hepatic I/R injury, indicating the potential factors/signaling pathways involved in this event and available therapeutic approaches that may help to improve controlling hepatic I/R during liver surgery.

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Keywords

ischemia/reperfusion, Kupffer cells, oxidative stress, mitochondrial damage, NF-kB, tumor necrosis factor

How to Cite
Abdel-Ghany, S. A. ., Elashry, H. A. ., Ameen, M. M. ., Abdel-Rahman, K. M. ., & Yassin, A.-R. A. . (2018). Hepatic Ischemia-Reperfusion Injury: Pathogenesis and Pharmacological Treatment: Submitted: Dec 11, 2017 Accepted: Jan 28, 2018 Published online: Feb 5, 2018. Advances in Medicine and Medical Research, 1(1), 2–18. https://doi.org/10.31377/ammr.v1i1.492
Section
Review Articles
Author Biography

Sameh A. Abdel-Ghany, Department of Clinical Pharmacology, Mansoura University Faculty of Medicine, Mansoura 35516, Egypt

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Corresponding Author:

Email: samghany@mans.edu.eg

Tel: 00201003798288